In another study, PSMA was encoded into human thyroid carcinoma cells by CRISPR-Cas9 and tracked by ACUPA-Cy3-BF3, a small-molecule that delivers positron-emitting fluoride (18F) and a fluorophore (Cy3) to report PSMA expression (Guo et al., 2019). This evidence concerns the gene FOLH1 and thyroid gland carcinoma.