VKORC1 and hyperthyroidism: Interestingly, many drugs were linked to at least one nuclear receptor: 134 drugs were connected to the MIE 1181 “Activation, Estrogen receptor,” 131 drugs were connected to the MIE 1134 “Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone,” and 110 drugs were connected to the MIE 245 “Activation, PXR/SXR.” Among the most linked drugs, propylthiouracil, used to treat hyperthyroidism was connected to the maximum number of events (12 events).