In addition, obesity disturbs endocrine hormones, such as leptin, and leads to the increase of adipose tissue-specific molecules, called adipokines, generating an altered immunity that favors the intensification of the SARS-CoV-2 infection and exacerbation of the mitochondrial damage (Saleh et al., 2020). The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.