The Venn map showed that there were 13 species of intestinal flora in colorectal cancer and normal human that have significant differences in abundance and 9 species in colorectal cancer and adenoma, where the Pc, Gm, Pm, Cs, and Ps bacteria achieved statistical differences simultaneously in both groups of controls (Log2Ratio > 3, P < 0.05, Figure 1C). Here, PRB1 is linked to adenoma.