FLT3 and acute myeloid leukemia: Midostaurin, which is approved for use in patients with newly diagnosed FLT3-mutated AML based on the RATIFY trial (85), in combination with azacitidine was investigated in a phase I/II trial in newly diagnosed, unfit and relapsed/refractory AML that enrolled primarily patients with FLT3 mutations (74%), and demonstrated a dramatically reduced response duration (median 6 weeks) in patients who had received a prior allo-HCT compared to those who had not (74).