In a murine transplant model, pre-transplant NK cell depletion through BCL-2 inhibition/knock-out leads to improved engraftment, and also improves survival without worsening GVHD in mice inoculated with an MLL-rearranged AML that is insensitive to BCL-2 inhibition (58). This evidence concerns the gene BCL2 and acute myeloid leukemia.