FLT3 and acute myeloid leukemia: A study of FLT3-ITD AML patients who had relapsed a median of just 2.8 months post-transplant demonstrated a 39% remission rate in those treated with sorafenib with dramatically improved survival compared to a control group that did not receive sorafenib salvage, and a 2-year OS of 38% among those treated with sorafenib of whom 33% and 13% received subsequent DLI or a second allo-HCT, respectively (77).