TNFAIP3 and neoplasm: In the present study, the expression of A20 in HCC tissues was higher than in non-tumor tissues, but A20 itself may not affect the activity of the pro-survival/anti-apoptosis related downstream factors of NF-κB in HCC cells (overexpression and knockdown of A20 expression did not affect the pro-survival/anti-apoptosis related downstream factors of NF-κB (Figure 6).