Among the most commonly highlighted genetic mutations in HCC, TP53 gene mutations are mutually exclusive with CTNBB1 mutations and HCCs with these aberrations have been suggested to have specific features in terms of tumor microenvironment (TME) (72); in fact, according to recent studies these malignancies report higher Foxp3+ Treg infiltration and lower CD8+ T cell infiltration (73). This evidence concerns the gene TP53 and hepatocellular carcinoma.