IRS2 and neoplasm: Further screening for proteins related to tumor growth, invasion, and metastasis, and regarding IRS2, IGF2, and its role-related gene ATG12, it was found that IRS2 and IGF2 were highly expressed in the gastric group than in the intestinal and pancreatic groups, and ATG12 was highly expressed in the gastric and pancreatic groups compared with the intestinal group (Supplementary Table S3).