AICDA and B-cell chronic lymphocytic leukemia: These include age-related mutagenesis reflecting a predilection of CLL for the elderly population, as well as activation-induced cytidine deaminase (AID) and APOBEC-related mutagenic processes that reflect CLL as a mature B cell malignancy putatively derived from antigen-experienced B cells with capacity for AID/APOBEC-mediated somatic hypermutation (42, 71, 73).