reported total regression of large established orthotopic HER2-expressing breast cancers up to 3,000 mm3 in the mouse TUBO model after the vaccination with a recombinant adenovirus (Ad) expressing the extracellular domain (ECD) and transmembrane domain (TMD) (ECTM) of rodent HER2. The gene discussed is ERBB2; the disease is breast carcinoma.