EGFR and non-small cell lung carcinoma: The four studies were BR.21 (erlotinib in second- and third-line stages III-IV NSCLC) (34), BR19 (adjuvant gefitinib in completely resected stages IB-IIIA NSCLC) (35), BR.26 (dacomitinib in stages IIIB-IV NSCLC after first-line chemotherapy and EGFR TKI) (36), and TOPICAL (first-line erlotinib in advanced stage NSCLC unsuitable for chemotherapy) (29).