Lorlatinib is often more effective for patients who fail to be treated well using the second-generation ALK-TKI, and it is very important to further study the plasma and tissue genotyping of ALK mutations and make a prospective prediction of ALK-TKI types for ALK resistance mutations of patients, which is very important for ALK TKI selection of advanced ALK-positive NSCLC patients (143, 144). The gene discussed is ALK; the disease is non-small cell lung carcinoma.