Also, talazoparib and APE inhibitor III shows remarkable antileukemia effect, meanwhile, low dose of talazoparib and APE inhibitor can enhance the cytotoxicity of decitabine inmyelodysplastic syndromes/chronic myelomonocytic leukemia and acute myeloid leukemia (139). This evidence concerns the gene APEX1 and chronic myelomonocytic leukemia.