In addition to this, idelalisib can collaborate with 5-FU or regorafenib to induce colon cancer apoptosis, with PUMA involvement in the process, which can serve as the sensitivity index of idelalisib in the treatment of colon cancer, and it is also the main factor of the role of idelalisib of anticolon cancer (61). Here, BBC3 is linked to colonic neoplasm.