Figure 5C showed that the expression of FNDC3B was remarkably increased in the stepwise progression of CCa, from normalcy to CIN and CCa. In addition, BPGM in the M7 module could differentiate all stages of progression of CCa in GSE138080 (Figure 5D), although the BPGM did not change between the three groups (Figure 5E). In 48 cervical samples, BPGM could differentiate all stages in the stepwise progression of CCa (Figure 5F). This evidence concerns the gene FNDC3B and cervical squamous intraepithelial neoplasia.