Six genes (GSTA1, GSTA2, NAT8, SLC17A3, SLC17A4 and FABP7) were screened out, given their downregulation in ccRCC patients with wild-type VHL. Furthermore, GO enrichment analysis illustrated that DEGs mentioned above were all involved in the pathway of cancer. This evidence concerns the gene NAT8 and nonpapillary renal cell carcinoma.