In order to explore the efficacy and safety of SCA as a single agent or combined with chemotherapy in the second-line treatment of patients with advanced NSCLC, we designed and carried out a randomized, open-label, national multi-center phase III clinical trial, including selected patients with advanced/metastatic NSCLC with wild-type or unknown EGFR status following failure of first-line platinum regimens. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.