Subgroup analysis shows that there were no statistically significant difference in mOS was observed among histological type (Adenocarcinoma vs. Squamous cell carcinoma, Supplementary Figure 1A, p=0.558) and EGFR status (Wild-type vs. Unknown, Supplementary Figure 1B, p=0.163). The gene discussed is EGFR; the disease is adenocarcinoma.