revealed the function of FBLN3 and FBLN5 as suppressors of lung cancer invasion and metastasis through the inhibition of Wnt/β-catenin and ERK signaling pathways (33) that, in turn, downregulate MMP-2 and MMP-7 expression (32) and inhibit lung cancer cell survival, proliferation, and metastasis (34, 35). The gene discussed is EFEMP1; the disease is lung carcinoma.