Again, HA is implicated in EMT through EGF or TGF-β1 signaling in lung cancer cell line A549, where TGF-β1 upregulates HAS1, HAS2, and HAS3 expressions and augments CD44 expression interacts with EGFR, leading to the activation of the downstream signaling AKT and ERK pathways (139). This evidence concerns the gene CD44 and lung carcinoma.