FN1 and non-small cell lung carcinoma: In NSCLC H1838 and H1792 cells, FN induces phosphorylation of eukaryotic initiation factor 4E–binding protein 1 (4E-BP1) and p70S6K1(two downstream targets of mTOR), and Akt phosphorylation (an upstream inducer of mTOR), whereas it inhibits the tumor suppressor protein phosphatase that antagonizes the PI3K/Akt signal (68).