If the SAMHD1 expression was combined with MIPI score, the PFS (p = 0.037) and OS (p = 0.029) of MCL patients with SAMHD1 positive and MIPI score more than 5 were much lower and the outcome of the patients was poorer compared with SAMHD1 negative with MIPI score less than 5 (Figures 4C, D). The gene discussed is SAMHD1; the disease is mantle cell lymphoma.