The role of IL-6/STAT3 signaling pathway in stimulating origination of inflammation and cancer was initially discovered by researchers, it was found that interferons (IFNs) and IL-6 were able to regulate the activity of downstream signaling molecules, which play an important role in tumorigenesis and development by regulating downstream transcription factors and can serve as a potential target for cancer therapy. This evidence concerns the gene IL6 and cancer.