A study of HBV-induced liver fibrosis, cirrhosis and HCC in mouse model (60), the DTNA/STAT3 signaling pathway can be activated and in turn further activates the STAT3 signaling pathway, stimulating expression of TGF-1, thus promoting the progression of HBV-induced liver fibrosis, cirrhosis, and HCC. Here, STAT3 is linked to Hepatic fibrosis.