In the classical signaling transduction pathway, IL-6 contacts mIL-6R on the membrane, causes dimerization and then starts transduction of signaling, mainly participating in autoimmunity, metabolism, tumor development, etc. During signal transduction, first, IL-6 binds with sIL-6R, and then the complex binds with membrane gp130. The gene discussed is IL6R; the disease is neoplasm.