IL-6, as a classic extracellular stimulation factor of this signaling pathway, during the hepatocarcinogenesis and HBV or HCV stimulates initiation of HCC, the secretion of IL-6 is emerged in the microenvironment of liver tissue cells, then IL-6 interaction with its receptor, conformation of IL-6 changes after binding with its receptor, and then activation of gp130 on the cell membrane surface to trigger isodimer formation of gp130, thus leading to activation of Janus kinases(JAKs). The gene discussed is IL6; the disease is hepatocellular carcinoma.