Moreover, it is demonstrated that as regulator of glutamate, glutamine, and cytokine release, Netrin G1 (NetG1) in CAFs and Netrin G1 Ligand (NGL-1) in pancreatic cancer cells enhanced tumorigenesis by allowing cancer cells to survive in low nutrient conditions and reduced death induced by NK cells (7). The gene discussed is NTNG1; the disease is pancreatic neoplasm.