In previous studies, Y-box sequence, as a cis-acting element, up-regulated ceramide synthase 6 through the transcriptional regulation of YBX1 to promote lamellipodia formation as well as migration activity, and up-regulated TGFBR1 to promote the stemness and EMT of lung cancer cells (45, 46). The gene discussed is TGFBR1; the disease is lung cancer.