First, based on multiple databases, we found that ELK3 overexpression was closely related to the poor prognosis of patients with gliomas, based on CGGA RNG-seq (P < 0.001, Figure 2A), CGGA microarray (P < 0.001, Figure 2B), and TCGA RNA-seq (P < 0.001, Figure 2C) databases. Here, ELK3 is linked to central nervous system cancer.