ELK3 and central nervous system cancer: Based on the TCGA RNA-seq database, the multivariate regression analysis revealed that ELK3 (P < 0.001, [HR] = 1.047 [95% CI [1.021–1.073]), age (P < 0.001, [HR] = 1.046 (95% CI [1.035–1.059])), and grade (P < 0.001, [HR] = 2.736 [95% CI [2.130–3.513])) were independent risk factors for poor prognosis in gliomas patients (Figure 2I).