Based on the TCGA RNA-seq database, the univariate regression analysis indicated that ELK3 (P < 0.001, [HR] = 1.119 [95% CI [1.098–1.141]), age (P < 0.001, [HR] = 1.072 (95% CI [1.061–1.083])), and grade (P < 0.001, [HR] = 4.634 (95% CI [3.727–5.760]) were risk factors for poor prognosis in gliomas patients (Figure 2F). Here, ELK3 is linked to central nervous system cancer.