Based on the CGGA RNA-seq database, the multivariate regression analysis revealed that ELK3 (P < 0.001, [HR] = 1.285 [95% CI [1.142–1.447]), PRS type (P < 0.001, [HR] = 1.961 [95% CI [1.666–2.308])), grade (P < 0.001, [HR] = 2.707 [95% CI [1.982–3.697)), and age (P < 0.001, [HR] = 1.301 [95% CI [1.065–1.590]) were independent risk factors for poor prognosis in gliomas patients (Figure 2G). The gene discussed is ELK3; the disease is central nervous system cancer.