Taken together with the high affinity and high sensitivity features of CD44-Apt1 to CD44E/s proteins, CD44-Apt1 could work as an efficient mediator to transport anti-cancer drugs, like 5-FU among others, into CD44E/s-expressing HCC tumor cells for enhanced intracellular drug loadings and thereof cytotoxic response. Here, CD44 is linked to hepatocellular carcinoma.