Such functionalized nanoprobes have been widely explored to target the biomarker receptors, which are overexpressed on the surface of several cancer cells, such as folate receptor, epidermal growth factor receptor (EGFR), transferrin receptor, asialoglycoprotein, low-density lipoprotein receptor, etc.103-107 Antibodies and their fragments have long been the traditionally used active targeting moiety. This evidence concerns the gene EGFR and cancer.