CDKN2A and histiocytic sarcoma: Myc is commonly over expressed in hepatocellular carcinomas (HCC)142 while inactivation of Ink4A/Arf-/- can lead to the development of histiocytic sarcomas, soft tissue sarcomas, and lymphomas.141 The authors demonstrated that SERS contrast agents accumulate in healthy liver tissues but not in liver tumors giving rise to high contrast, high resolution Raman imaging.