Buprenorphine is a partial mu-opioid receptor agonist effective in maintenance pharmacotherapy of OUD due to its long half-life, greater safety in overdose compared to full mu-opioid receptor agonists, and decreased incidence of opioid-induced side effects like respiratory depression, constipation, and tolerance [3-5]. The gene discussed is OPRM1; the disease is Respiratory insufficiency due to muscle weakness.