In contrast, the downregulated genes unique to the cell types are involved in signaling pathways such as NOD-like, TNF, T-cell receptor, MAPK, HIF-1, p53, PI3K-Akt, insulin, hippo, Rap1 and mechanisms such as thyroid hormone synthesis, cytosolic DNA-sensing pathway, apoptosis, ferroptosis, transcriptional misregulation in cancer, natural killer cell mediated cytotoxicity, central carbon metabolism in cancer, homologous recombination, pyrimidine and gluthathione metabolism, CAMs etc. Here, TP53 is linked to cancer.