Conversely, the common TP downregulated genes participate in PI3K-Akt, Rap1, hippo, cAMP, apelin, p53, chemokine, B-cell receptor, NOD-like, PPAR, negative regulation of TGF-β, PDGFR, CD40, TLR5, Notch signaling pathways and processes like cell cycle, apoptosis, pyroptosis, somatic stem cell division, negative regulation of cell population proliferation and growth, activation of NF-kappaB-inducing kinase activity, tumour progression, cell motility and T-cell regulation (Supplementary Table. This evidence concerns the gene APLN and neoplasm.