STAT3 and Sepsis: To further confirm that the anti-sepsis effects of curcumin in vivo were primarily due to the inhibition of mitochondrial STAT3 knock-in macrophages by curcumin, we intercrossed Rosa26LSL-MLS-mSTAT3 mice with LyzCre/+ mice and treated the LPS-induced septic mice with either control diluent or curcumin.