As illustrated in Figure 3A, PMA-differentiated THP1 human monocytes were co-cultured with HT29 human colorectal cancer cells with or without HMGA2 overexpression (HT29-NC and HT29-A2, respectively), while RAW264.7 cells were co-cultured with CT26 murine colorectal cancer cells with or without Hmga2 KO (CT26-NC and CT26-sgA2, respectively). The gene discussed is DDX53; the disease is colorectal cancer.