Also, we have previously shown that the overexpression of Lrp5 and β-catenin in Wnt signaling, Akt in PI3K signaling, and Snail in the induction of epithelial-to-mesenchymal transition can grant osteocytes, mesenchymal stem cells (MSCs), and tumor cells tumor-suppressing capabilities 13, 14. Here, LRP5 is linked to neoplasm.