To elucidate the mechanism of the anti-tumor action of Hsp90ab1 and MSN, we evaluated their downstream protumorigenic genes such as TGFβ, Runx2, Snail, and MMP9, as well as PDL1 24 that inhibits immune responses and KDM3A 25 that regulates histone methylation. The gene discussed is HSP90AB1; the disease is neoplasm.