Silencing CD44 and FN1 in EO771 cells and MDA-MB-231 cells downregulated MTT-based viability as well as the expression of Lrp5, MMP9, Runx2, and Snail in EO771 cells, whereas their silencing significantly suppressed MSN-induced tumor inhibition (Figure 7D-E, Figure S10B-D). This evidence concerns the gene RUNX2 and neoplasm.