In the placebo group, a large number of tumor cells were visible in the lung in 3 weeks, whereas the daily administration of Lrp5 CM for 3 weeks as an intravenous injection significantly reduced the size of tumor-invaded areas in the lung and the expression of oncogenic genes such as Runx2 and Snail in the lung (Figure 3A-B). This evidence concerns the gene RUNX2 and neoplasm.