To elucidate the mechanism of the anti-tumor action of Hsp90ab1 and MSN, we evaluated their downstream protumorigenic genes such as TGFβ, Runx2, Snail, and MMP9, as well as PDL1 24 that inhibits immune responses and KDM3A 25 that regulates histone methylation. This evidence concerns the gene MMP9 and neoplasm.