Abundant evidence suggests oxidative stress, as well as infiltration of immune cells and their secreted cytokines (e.g., interferon gamma (IFN-γ), interleukin-4 (IL-4), IL-9, IL-17, IL-22) 7, 8, be involved in vascular remodeling, and thus crucial mediators of AD. Here, IFNG is linked to Alzheimer disease.