We selected NF-κB signaling, BMP signaling, PPARα and PTEN signaling pathways to investigate the roles of these pathways in FB2 state switching, and used compounds to selectively activate (Oroxin B for PTEN signaling, GW7647 for PPAR activation) or inhibit (PDTC for NF-κB signaling, LDN-193189 for BMP signaling) them in a mouse model of AD (Figure 8C). This evidence concerns the gene PPARA and Alzheimer disease.