IFNG and neoplasm: Fortunately, the proinflammatory cytokine interferon γ (IFN-γ) secreted by tumor-infiltrating T lymphocytes can induce ferroptotic cell death by inhibiting the expression of endogenous SLC7A11 and SLC3A2 proteins, and the formed LPO acts as a localization signal to promote the phagocytosis of tumor cells by dendritic cells (DCs), thereby eliciting the immunogenicity of tumor cells 92, 93.