Owing to the opening of the ultrasound-targeted microbubble destruction (UTMD)-mediated transient blood brain barrier (BBB), angiopep-2-modified nanoliposomes could selectively target glioma cells with high expression of low-density lipoprotein receptor-related protein 1 (LRP1) based on ligand-receptor binding. The gene discussed is LRP1; the disease is glioma.