Combined with αPD-L1, the BNP@R nanoplatform under laser irradiation effectively caused more than 2.0-fold higher intratumoral infiltration of IFN-γ+CD8+ T lymphocytes, dramatically inhibited the growth of B16-F10 melanoma tumors and the metastasis of 4T1 breast tumors, and significantly improved the survival rate of tumor-bearing mice by 35% within 50 days of the final treatment, indicating the prospective potential of ferroptosis-promoted immunotherapy. The gene discussed is IFNG; the disease is neoplasm.