The ability of the PCA3-Cre-PSEBC-ITSTA system to assess the sensitivity of LNCaP (sensitive), LAPC4 (moderately resistant) and 22Rv1 (resistant) PCa cell lines to two ARATs, Enza and Bica 38, 39, was evaluated using a linear discriminate approach. This evidence concerns the gene PCA3 and posterior cortical atrophy.