PCA3 and posterior cortical atrophy: We first tested the ability of PCA3-Cre-PSEBC-ITSTA to signal specifically in PCa cells. PCA3-Cre-PSEBC-ITSTA generated Luc activity was more than 1500-times higher in 22Rv1 PCa cells when compared to non-prostatic CAMA-1 or ZR-75-1 cells.