Among them, protein tyrosine kinase-2 (PTK2), phosphatidylinositol 3-kinase (PI3K, PIK3R1), SRC, and serum/glucocorticoid regulated kinase-3 (SGK3) were upregulated in pressurised liver cancer cells; forkhead box O1 (FOXO1) and cyclin dependent kinase inhibitor 1 B (CDKN1B, P27Kip1) were downregulated; phosphoinositide dependent protein kinase 1 (PDK1) showed no statistically significant changes in expression. The gene discussed is PTK2; the disease is liver cancer.