A recent study reported that the STIP1 homology Stub1 is necessary for protective degradation of ROS-stressed peroxisomes 33, we thus postulate that the ROS-STIP1 signaling, in maintaining a delicated balance of intracellular ROS level, is critical for RCC cells to detoxify from ROS and contributes to bone metastasis. This evidence concerns the gene STUB1 and renal cell carcinoma.