A large number of studies have shown that PES1 is related to tumor cell proliferation, invasion and metastasis of multiple types of cancer, including prostate cancer 12, 13, liver cancer 14-18, pancreatic cancer 19, papillary thyroid cancer (PTC) 20, breast cancer 21-24, ovarian cancer 25, gastric cancer (GC) 26, neuroblastoma 27, colon cancer 28, and others. This evidence concerns the gene PES1 and Familial prostate cancer.