After knocking down PES1, Fan et al. found that the mRNA levels of GLUT1, ENO1 and PKM2 were downregulated, while the mRNA levels of FBP1 and PCK1were upregulated, and glucose uptake and lactate excretion of liver cancer cells were reduced, which indicated that glycolysis in HCC was reduced 17. The gene discussed is PES1; the disease is hepatocellular carcinoma.