Moreover, MARVELD1 promoter locus hypermethylation inversely and significantly affected the expression of MARVELD1 in BLCA, cholangio carcinoma (CHOL), COAD, head and neck squamous cell carcinoma (HNSC), kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), pancreatic adenocarcinoma (PAAD), pheochromocytoma and paraganglioma (PCPG), sarcoma (SARC), skin cutaneous melanoma (SKCM), thyroid carcinoma (THCA), thymoma (THYM), and UCEC (Figure 3B-N). The gene discussed is MARVELD1; the disease is colon adenocarcinoma.