Furthermore, PFKFB4 participates in multiple steps of cancer development, such as 1) PFKFB4 mediates the tumorigenesis of thyroid cancer by negatively regulating expression of histone acetyltransferase GCN5 11, 2)PFKFB4 promotes breast cancer metastasis via induction of hyaluronan production 12, and 3) PFKFB4 modulates chemoresistance of small-cell lung cancer by regulating autophagy 13. Here, PFKFB4 is linked to breast cancer.