We found that Tumor size (P=0.001), TNM staging (P<0.001), Serum AFP level (P=0.011), BCLC staging (P<0.001), CLIP staging (P=0.001), Multinodular (P=0.023), Cirrhosis (P=0.023), and high SNRPD1 expression (P=0.003) were risk factors for overall survival of HCC by performing Univariate Cox Regression analysis. Here, AFP is linked to hepatocellular carcinoma.