The Multivariate Cox Regression analysis confirmed that BCLC staging (HR (95%CI): 5.381(2.985-9.700); P<0.001), Multinodular (HR (95%CI): 2.012(1.082-3.740); P=0.027), Cirrhosis (HR (95%CI): 0.206(0.050-0.839); P=0.028) and high SNRPD1 expression (HR (95%CI): 1.968(1.266-3.060); P=0.003) were independent risk factors for overall survival. The gene discussed is SNRPD1; the disease is Cirrhosis.