Moreover, the addition of the CXCR4 inhibitor AMD3100 (plerixafor) along with radiotherapy and chemotherapy returned CXCL12, pCXCR4, pERK, PD-L1, Ly6G, and F4/80 expression to near control levels and was associated with a decreased tumor volume 38. The gene discussed is CXCL12; the disease is neoplasm.