Somatic BAP1 mutations in HCC were present predominantly in women, and mutation rate of BAP1 was significantly high in white patients than in Asian patients, whether the sex and race bias in BAP1 mutation status is the result of a biological difference or a sampling issue remains unclear, but a meta-analysis including 12 studies with 3447 participants also revealed that BAP1 mutation was more common in women than in men in different types of cancer 22. The gene discussed is BAP1; the disease is hepatocellular carcinoma.