It has been revealed that phosphorylation of PEA15 has promoted the proliferation and invasion of gastric cancer cells via ERK phosphorylation 35, whereas the unphosphorylated state has inhibited the ERK and EGFR phosphorylation, thus inhibiting proliferation, invasion and metastasis of breast and ovarian cancer 39. The gene discussed is EGFR; the disease is ovarian carcinoma.