PEA15 and hepatocellular carcinoma: In this study, miR-449a-5p enhanced the efficacy of sorafenib via silencing PEA15, PPP1CA and TUFT1. These results are in line with Yang et al. who have reported that the miR-449a-5p related miR-34 reduces cell viability, promotes cell apoptosis and enhances sorafenib-induced apoptosis in HCC cell lines 47.