Results using a stably transduced cell line with interference of hsa_circ_0074298 expression and transient transfection of miR-519d inhibitor or SMOC2 overexpression plasmids suggested that hsa_circ_0074298 played a biological role through the miR-519d/SMOC2 axis to regulate the proliferation, migration, and invasion of pancreatic cancer cells, indicating that hsa_circ_0074298 was closely associated with the malignant progression of pancreatic cancer. Here, SMOC2 is linked to familial pancreatic carcinoma.