However, the decrease in gemcitabine resistance induced by downregulation of hsa_circ_0074298 in panc-1-GEM could be reversed by cotransfection of miR-519d inhibitor or SMOC2 overexpression, further verifying that hsa_circ_0074298 regulated pancreatic cancer through the miR-519d/SMOC2 axis in vitro and in vivo. Here, SMOC2 is linked to familial pancreatic carcinoma.