A significantly lower tumor volume and weight were found in the sh-circ0074298 group compared with the sh-NC group (P<0.001); the tumor volume and weight increased significantly in the sh-circ0074298+miR-519d inhibitor and the sh-circ0074298+SMOC2 overexpression groups compared with that in the sh-circ0074298 group (P<0.001) (Figure 6B, C), providing in vivo confirmation of the in vitro cell experiment results. The gene discussed is SMOC2; the disease is neoplasm.