ITCH and familial pancreatic carcinoma: Bladder cancer studies have found that the circRNA ITCH regulates the expression of p21 and phosphatase and tensin homologue (PTEN) by sponging miR-17/miR-224 10; in pancreatic cancer, the circRNA LDLRAD3 can be used as a biomarker for pancreatic cancer diagnosis 11, and circRNA_100782 can regulate the proliferation of pancreatic cancer cells through IL6-STAT3 signaling 12.