In addition, recent studies have suggested that recombination of Sox-2, Oct-4, Klf-4, Nanog, lin28A and lin28B in tumor cells, such as lung adenocarcinoma cancer16, melanoma17 and pancreatic cancer cells18, also induces stemness features with relatively high expression of stem cell markers and a relatively strong tumorigenesis capacity. This evidence concerns the gene POU5F1 and neoplasm.