ESR1 and major depressive disorder: The PPI network of CCHP in treating depression (Figure 3(b)), which was visualized and analyzed using Cytoscape, illustrated that AKT1, IL-6, TP53, DRD2, MAPK1, NR3C1, TNF, ESR1, SST, OPRM1, DRD3, ADRA2A, and ADRA2C were core targets of CCHP in treating depression.