CCHP treated depression by acting on multiple key targets, such as AKT1, IL-6, TP53, DRD2, MAPK1, NR3C1, TNF, ESR1, SST, OPRM1, DRD3, ADRA2A, and ADRA2C, and through important biological processes, such as positive regulation of transcription from RNA polymerase II promoter, plasma membrane, and protein binding. Here, ESR1 is linked to major depressive disorder.