TGFB1 and geroderma osteodysplastica: Then, 5 miRNAs of interest were verified as being involved in the pathogenesis of GO in previous research: miR-146a plays a negative regulatory role in the regulation of fibrosis in GO patients (Jang et al., 2018), and miR-155 is indispensable in the formation of fibrous tissue and mediates the TGF-β signaling pathway to drive collagen synthesis in GO patients (Li et al., 2014).