This is the case of LHON, where one of the most prevalent variants that accounts for more than 70% of all cases is the m.11778G > A, located in the MT-ND4 gene (Yu-Wai-Man et al., 2014; Mancuso and Klopstock et al., 2019). Here, MT-ND4 is linked to Leber hereditary optic neuropathy.