MT-ND4 and optic nerve disorder: Our findings are consistent with evidence from the literature that suggest a potential role of the mtGenome, and more specifically of the genes MT-ND4 and MTCYB in optic neuropathies or glaucoma (Cortopassi and Arnheim et al., 1990; Votruba et al., 2004; Abu-Amero et al., 2006).