IL13RA2 and central nervous system cancer: Similarly, the use of CAR T cells targeting IL13Rα2 was shown to lead to improved survival in preclinical murine models, but recurrent gliomas post-treatment experienced downregulation of the target antigen, suggesting that the use of CAR T cells targeting a singular antigen may select for GBM cells that lack expression and subsequently allow for disease progression (Krenciute et al., 2017).