Dual radiation and anti-GITR therapy has also been associated with improved survival via increased CD4+ effector T cell infiltration and IFN-γ, IL-2, and TNF-α secretion, suggesting that the two modalities synergize and highlighting the immune sensitizing effects of radiotherapy on the tumor microenvironment (Patel et al., 2016). The gene discussed is CD4; the disease is neoplasm.