PTGS2 and congestive heart failure: Alternatively, it may also be appropriate to shift focus towards PGE2 as a therapeutic target rather than COX2 itself, especially given the broad range of well-known adverse effects associated with COX2 inhibition such as hypertension, congestive heart failure exacerbation, renal impairment, and other cardiovascular events (Mukherjee et al., 2001; Wright, 2002).