ZEB1 and breast carcinoma: Many studies have revealed that TFs regulate gene expression by interacting with miRNAs, for example, Mangalhara et al. revealed the zinc finger E-box binding homeobox 1(ZEB1) can downregulate miR-101 expression by regulating miR-101-1 promoter and induce Epithelial-Mesenchymal Transition (EMT) in breast cancer (Chandra Mangalhara et al., 2017).