Besides, KEGG pathway analysis revealed that these IRDEGs were chiefly enriched in immune-related pathways, such as cytokine−cytokine receptor interaction, Viral protein with cytokine receptor, T cell receptor signaling pathway, Chemokine signaling pathway, Natural killer cell mediated cytotoxicity, PD−L1 expression and PD−1 checkpoint pathway in cancer (Figure 3B). This evidence concerns the gene CD274 and cancer.