The result show that, as compared to the cohorts lacking any susceptibility alleles, cohorts carrying the HLA-B*08:01-DRB1*03:01-DQB1*02:01 risk haplotype had a strong association with immune pathways including interferon-gamma signalling, TCR signalling, PD1 signaling, antigen processing and presentation as well as various immune diseases such as asthma, SLE and T1D. This evidence concerns the gene HLA-B and type 1 diabetes mellitus.