According to Pietilä et al. (2019), the depletion of SORL1 triggers HER2 accumulation in dysfunctional lysosomes, and SORL1-silenced cells showed antiproliferative effects on not only breast cancer but also bladder cancer by regulating oncogenic receptor tyrosine kinase (RTK) signaling. This evidence concerns the gene ERBB2 and urinary bladder carcinoma.