According to Pietilä et al. (2019), the depletion of SORL1 triggers HER2 accumulation in dysfunctional lysosomes, and SORL1-silenced cells showed antiproliferative effects on not only breast cancer but also bladder cancer by regulating oncogenic receptor tyrosine kinase (RTK) signaling. The gene discussed is ERBB2; the disease is urinary bladder cancer.